Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct Patterns of Clonal Evolution Drive Myelodysplastic Syndrome Progression to Secondary Acute Myeloid Leukemia.

Blood cancer discovery - 6 Jul 2022

Guess Tiffany, Potts Chad R, Bhat Pawan, Cartailler Justin A, Brooks Austin, Holt Clinton, Yenamandra Ashwini, Wheeler Ferrin C, Savona Michael R, Cartailler Jean-Philippe, Ferrell P Brent

Abstract excerpt

Clonal evolution in myelodysplastic syndrome (MDS) can result in clinical progression and secondary acute myeloid leukemia (sAML). To dissect changes in clonal architecture associated with this progression, we performed single-cell genotyping of paired MDS and sAML samples from 18 patients. Analysis of single-cell genotypes revealed patient-specific clonal evolution and enabled the assessment of single-cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clonal Evolution
Share to Clone Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Myelodysplastic Syndromes

Share to Neoplasms, Second Primary

Source

Open in PubMed Open full text

Identifiers

PMID: 35522837
DOI: 10.1158/2643-3230.BCD-21-0128
PMCID: PMC9610896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct Patterns of Clonal Evolution Drive Myelodysplastic Syndrome Progression to Secondary Acute Myeloid Leukemia.PMID 35522837Read ↗

Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes.Semantic proximity Read ↗

Clonal architecture of secondary acute myeloid leukemia.Semantic proximity Read ↗

Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.Semantic proximity Read ↗

Gene mutations and clonal architecture in myelodysplastic syndromes and changes upon progression to acute myeloid leukaemia and under treatment.Semantic proximity Read ↗

Dynamics of clonal evolution in myelodysplastic syndromes.Semantic proximity Read ↗

The clonal origins of leukemic progression of myelodysplasia.Semantic proximity Read ↗

Genetics of progression from MDS to secondary leukemia.Semantic proximity Read ↗

Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.Semantic proximity Read ↗

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure.Semantic proximity Read ↗

Single-cell mutation analysis of clonal evolution in myeloid malignancies.Semantic proximity Read ↗

Evolutionary trajectories of myelodysplastic syndromes/neoplasms.Semantic proximity Read ↗

Clonal evolution in myelodysplastic syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.