Article
Clonal architecture of chronic myelomonocytic leukemias.
Blood - 21 Mar 2013
Itzykson Raphaël, Kosmider Olivier, Renneville Aline, Morabito Margot, Preudhomme Claude, Berthon Céline, Adès Lionel, Fenaux Pierre, Platzbecker Uwe, Gagey Olivier, Rameau Philippe, Meurice Guillaume, Oréar Cédric, Delhommeau François, Bernard Olivier A, Fontenay Michaela, Vainchenker William, Droin Nathalie, Solary Eric
Abstract excerpt
Genomic studies in chronic myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), and MPN/MDS, have identified common mutations in genes encoding signaling, epigenetic, transcription, and splicing factors. In the present study, we interrogated the clonal architecture by mutation-specific discrimination analysis of single-cell-derived colonies in 28 patients with...
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