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Article

Sequence Diversity and Encoded Enzymatic Differences of Monocistronic L1 ORF2 mRNA Variants in the Aged Normal and Alzheimer's Disease Brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Jun 2025

Nicodemus Juliet, Liu Christine S, Ransom Linnea, Tan Valerie, Romanow William, Jimenez Natalia, Chun Jerold

Abstract excerpt

Reverse transcriptase (RT) activity in the human brain has been inferred through somatic retroinsertion/retrotransposition events; however, actual endogenous enzymatic activities and sources remain unclear. L1 (LINE-1) retrotransposons bicistronically express ORF2, containing RT and endonuclease (EN) domains, and RNA-binding protein ORF1, together enabling L1 retrotransposition and contributing to somatic genomic...

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Identifiers

PMID: 40368603
DOI: 10.1523/JNEUROSCI.2298-24.2025
PMCID: PMC12179785

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