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Article

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

1 Dec 2018

Abstract excerpt

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving loss of motor neurons and having no known cure and uncertain etiology. Several studies have drawn connections between altered retrotransposon expression and ALS. Certain features of the LINE-1 (L1) retrotransposon-encoded ORF1 protein (ORF1p) are analogous to those of neurodegeneration-associated RNA-binding proteins,...

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PMID: 30564290
DOI: 10.1186/s13100-018-0138-z

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