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LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma

27 Jan 2023

Abstract excerpt

Long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p) expression is a common feature of many cancer types, including high-grade serous ovarian carcinoma (HGSOC). Here, we report that ORF1p is not only expressed but also released by ovarian cancer and primary tumor cells. Immuno-multiple reaction monitoring-mass spectrometry assays showed that released ORF1p is confidently detectable in...

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PMID: 36707610
DOI: 10.1038/s41598-023-28840-5

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