Article

Mitotic systemic genomic instability in yeast

2017-09-17

Abstract excerpt

<h4>ABSTRACT</h4> Conventional models of genome evolution generally include the assumption that mutations accumulate gradually and independently over time. We characterized the occurrence of sudden spikes in the accumulation of genome-wide loss-of-heterozygosity (LOH) in Saccharomyces cerevisiae , suggesting the existence of a mitotic systemic genomic instability process (mitSGI). We characterized the emergence...

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Literature Corpus work: 02a8b39f-7d4b-5b2f-b940-d62b5f8b523b
DOI: 10.1101/161869

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