Burst of aneuploidy: a cost of adaptation driven by breakdown of cell cycle control.

Abstract excerpt

Complex genome rearrangements are intriguing because it remains unclear whether they occurred gradually or suddenly, and what promoted or impeded their development. We started by asking whether double loss of heterozygosity (dLOH) involving two different chromosomes is simply the result of two independent single LOH events. We examined hundreds of vegetatively growing diploid yeast strains with gene deletions...

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