A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.

doi:10.1093/brain/awab337

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Article

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.

Brain : a journal of neurology - 31 Dec 2021

Magusali Naciye, Graham Andrew C, Piers Thomas M, Panichnantakul Pantila, Yaman Umran, Shoai Maryam, Reynolds Regina H, Botia Juan A, Brookes Keeley J, Guetta-Baranes Tamar, Bellou Eftychia, Bayram Sevinc, Sokolova Dimitra, Ryten Mina, Sala Frigerio Carlo, Escott-Price Valentina, Morgan Kevin, Pocock Jennifer M, Hardy John, Salih Dervis A

Abstract excerpt

Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia. However, the function of OAS1 within microglia was not known. Using genotyping from 1313 individuals with sporadic Alzheimer's disease and 1234 control individuals, we confirm the OAS1 variant, rs1131454, is associated with increased risk...

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PMID: 34619763
DOI: 10.1093/brain/awab337
PMCID: PMC8500089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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