OAS1: A Protective Mechanism for Alzheimer's Disease? An Exploration of Data and Possible Mechanisms.

doi:10.3390/ijms26020524

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

OAS1: A Protective Mechanism for Alzheimer's Disease? An Exploration of Data and Possible Mechanisms.

International journal of molecular sciences - 9 Jan 2025

Elsworthy Richard J, Pearce Alex, Masoudzadeh Farnoush, Koska Klaudia, Lodhiya Honey, Meher Gargi, Adjej Jodelle, Brookes Keeley J

Abstract excerpt

The immune system and neuroinflammation are now well established in the aetiology of neurodegeneration. Previous studies of transcriptomic and gene association studies have highlighted the potential of the 2'-5' oligoadenylate synthetase 1 (OAS1) to play a role in Alzheimer's disease. OAS1 is a viral response gene, interferon-induced, dsRNA activated enzyme, which binds RNase L to degrade dsRNA, and has been...

Read the complete abstract on PubMed

Topics

Humans
2',5'-Oligoadenylate Synthetase
Alzheimer Disease
Polymorphism, Single Nucleotide
Aged
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

RNA, Double-Stranded

Aged, 80 and over

Genotype

Brain

Haplotypes

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 39859237
DOI: 10.3390/ijms26020524
PMCID: PMC11765370

Genes

OAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

OAS1: A Protective Mechanism for Alzheimer's Disease? An Exploration of Data and Possible Mechanisms.PMID 39859237Read ↗

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.Semantic proximity Read ↗

Genetic variability associated with <i>OAS1</i> expression in myeloid cells increases the risk of Alzheimer’s disease and severe COVID-19 outcomesSemantic proximity Read ↗

ADAR1 suppression causes interferon signaling and transposable element transcript accumulation in human astrocytesSemantic proximity Read ↗

OAS1 gene haplotype confers susceptibility to multiple sclerosis.Semantic proximity Read ↗

Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.Semantic proximity Read ↗

Mitochondrial double-stranded RNA accumulation in brain aging and Alzheimer’s diseaseSemantic proximity Read ↗

ADAR Dysfunction in Brain Aging and Alzheimer's DiseaseSemantic proximity Read ↗

A Novel Competing Endogenous RNA Linked to Dysregulated Neuroinflammation in Alzheimer’s DiseaseSemantic proximity Read ↗

Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism.Semantic proximity Read ↗

Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.Semantic proximity Read ↗

Gene Variants of the OAS/RNase L Pathway and Their Association with Severity of Symptoms and Outcome of SARS-CoV-2 InfectionSemantic proximity Read ↗

Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.