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Comparing Alzheimer's genes in African, European, and Amerindian induced pluripotent stem cell–derived microglia

1 Feb 2025

Abstract excerpt

INTRODUCTION: Genome-wide association studies (GWAS) studies in Alzheimer's disease (AD) demonstrate ancestry-specific loci. Previous studies in the regulatory architecture have only been conducted in Europeans (EUs), thus studies in additional ancestries are needed. Given the prevalence of AD genes expressed in microglia, we initiated our studies in induced pluripotent stem cell (iPSC) -derived microglia....

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PMID: 40008916
DOI: 10.1002/alz.70031

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