Article
Clonal hematopoiesis is associated with protection from Alzheimer's disease.
Nature medicine - 1 Jul 2023
Bouzid Hind, Belk Julia A, Jan Max, Qi Yanyan, Sarnowski Chloé, Wirth Sara, Ma Lisa, Chrostek Matthew R, Ahmad Herra, Nachun Daniel, Yao Winnie, Beiser Alexa, Bick Alexander G, Bis Joshua C, Fornage Myriam, Longstreth William T, Lopez Oscar L, Natarajan Pradeep, Psaty Bruce M, Satizabal Claudia L, Weinstock Joshua, Larson Eric B, Crane Paul K, Keene C Dirk, Seshadri Sudha, Satpathy Ansuman T, Montine Thomas J, Jaiswal Siddhartha
Abstract excerpt
Clonal hematopoiesis of indeterminate potential (CHIP) is a premalignant expansion of mutated hematopoietic stem cells. As CHIP-associated mutations are known to alter the development and function of myeloid cells, we hypothesized that CHIP may also be associated with the risk of Alzheimer's disease (AD), a disease in which brain-resident myeloid cells are thought to have a major role. To perform association...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.