Article

Clonal Hematopoiesis Mutations Increase Risk of Alzheimer’s Disease with <i>APOE</i> ε3/ε3 Genotype

2025-05-21

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) represents clonal expansion of blood cells, and increases the risk of hematological malignancies and cardiovascular disorders. Recent studies have studied CHIP mutations in individuals with Alzheimer’s disease (AD), but it is unclear whether their role in AD pathogenesis is protective, detrimental, or neutral. In this study, we used molecular-barcoded deep gen...

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Literature Corpus work: 26367266-ddae-5405-acb2-a5f8dc33d703
DOI: 10.1101/2025.05.19.654981

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