Article
Signatures of Selection in the Human Antibody Repertoire: Selective Sweeps, Competing Subclones, and Neutral Drift
2017-10-19
Abstract excerpt
Antibodies are created and refined by somatic evolution in B cell populations, which endows the human immune system with the ability to recognize and eliminate diverse pathogens. However, the evolutionary processes that sculpt antibody repertoires remain poorly understood. Here, using an unbiased repertoire-scale approach, we show that the molecular signatures of evolution are evident in human B cell lineages and...
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Identifiers and source
- Literature Corpus work
- 0247b709-2385-504f-869a-f3f0bf7e1529
- DOI
- 10.1101/145052