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Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching

1 Aug 2016

Abstract excerpt

Antibody class switching is a feature of the adaptive immune system which enables diversification of the effector properties of antibodies. Even though class switching is essential for mounting a protective response to pathogens, the in vivo patterns and lineage characteristics of antibody class switching have remained uncharacterized in living humans. Here we comprehensively measured the landscape of antibody...

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PMID: 27481325
DOI: 10.7554/elife.16578

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