Article

Biophysical trade-offs in antibody evolution are resolved by conformation-mediated epistasis

2026-03-13

Abstract excerpt

Protein evolution is constrained by multidimensional biophysical factors, in which mutations that enhance one property often compromise another. Antibodies represent an extreme case: they evolve rapidly to bind diverse antigens, yet mutations that improve affinity can disrupt folding, reduce cell-surface trafficking, or promote self-reactivity, and are typically selected against during affinity maturation. Though...

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Literature Corpus work: e0929688-aabb-5279-b1a3-ff17300b40e1
DOI: 10.64898/2026.03.12.711465

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