Dissecting human antibody responses: useful, basic and surprising findings.

doi:10.15252/emmm.201808879

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Article

Dissecting human antibody responses: useful, basic and surprising findings.

EMBO molecular medicine - 1 Mar 2018

Lanzavecchia Antonio

Abstract excerpt

Human memory B cells and plasma cells represent a rich source of antibodies that have been selected in response to human pathogens. In the last decade, different methods have been developed to interrogate the human memory repertoire and isolate monoclonal antibodies. I will discuss how a target-agnostic approach based on high-throughput screening of antibodies produced by cultured B cells and plasma cells has not...

Topics

Antibodies, Neutralizing
Antibody Formation
Humans
Mutation
Orthomyxoviridae
Polymorphism, Genetic
Receptors, Cell Surface
Vaccination

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Identifiers

PMID: 29363490
DOI: 10.15252/emmm.201808879
PMCID: PMC5840544

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