Article
Dissecting human antibody responses: useful, basic and surprising findings.
EMBO molecular medicine - 1 Mar 2018
Lanzavecchia Antonio
Abstract excerpt
Human memory B cells and plasma cells represent a rich source of antibodies that have been selected in response to human pathogens. In the last decade, different methods have been developed to interrogate the human memory repertoire and isolate monoclonal antibodies. I will discuss how a target-agnostic approach based on high-throughput screening of antibodies produced by cultured B cells and plasma cells has not...
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