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Article

Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties.

Frontiers in immunology - 1 Jan 2024

Georgaki Galateia, Mpakali Anastasia, Trakada Myrto, Papakyriakou Athanasios, Stratikos Efstratios

Abstract excerpt

Introduction: ER aminopeptidase 1 (ERAP1) is a polymorphic intracellular aminopeptidase with key roles in antigen presentation and adaptive immune responses. ERAP1 allotype 10 is highly protective toward developing some forms of autoimmunity and displays unusual functional properties, including very low activity versus some substrates. Methods: To understand the molecular mechanisms that underlie the biology of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39493758
DOI: 10.3389/fimmu.2024.1415964
PMCID: PMC11527673

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