Article
Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2011
Evnouchidou Irini, Kamal Ram P, Seregin Sergey S, Goto Yoshikuni, Tsujimoto Masafumi, Hattori Akira, Voulgari Paraskevi V, Drosos Alexandros A, Amalfitano Andrea, York Ian A, Stratikos Efstratios
Abstract excerpt
ER aminopeptidase 1 (ERAP1) customizes antigenic peptide precursors for MHC class I presentation and edits the antigenic peptide repertoire. Coding single nucleotide polymorphisms (SNPs) in ERAP1 were recently linked with predisposition to autoimmune disease, suggesting a link between pathogenesis of autoimmunity and ERAP1-mediated Ag processing. To investigate this possibility, we analyzed the effect that...
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