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Article

Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014

Reeves Emma, Colebatch-Bourn Alexandra, Elliott Tim, Edwards Christopher J, James Edward

Abstract excerpt

For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the mechanisms underlying this association are still unknown. Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum aminopeptidase 1 (ERAP1), which is essential for trimming peptides before they are presented to T cells by major...

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Share to Aminopeptidases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25422414
DOI: 10.1073/pnas.1408882111
PMCID: PMC4267330

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.PMID 25422414Read ↗

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