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Article

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties.

The Journal of biological chemistry - 1 Jan 2000

Hutchinson Jonathan P, Temponeras Ioannis, Kuiper Jonas, Cortes Adrian, Korczynska Justyna, Kitchen Semra, Stratikos Efstratios

Abstract excerpt

Polymorphic variation of immune system proteins can drive variability of individual immune responses. Endoplasmic reticulum aminopeptidase 1 (ERAP1) generates antigenic peptides for presentation by major histocompatibility complex class I molecules. Coding SNPs in ERAP1 have been associated with predisposition to inflammatory rheumatic disease and shown to affect functional properties of the enzyme, but the...

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Identifiers

PMID: 33617882
DOI: 10.1016/j.jbc.2021.100443
PMCID: PMC8024916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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