Article

Extrachromosomal DNA in the cancerous transformation of Barrett’s esophagus

2022-07-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Oncogenes are commonly amplified on extrachromosomal DNA (ecDNA) contributing to poor outcomes for patients. Currently, the chronology of ecDNA development is not known. We studied the origination and evolution of ecDNA in patients with Barrett’s esophagus (BE) who progressed to esophageal adenocarcinoma (EAC). <h4>METHODS</h4> We analyzed whole-genome sequencing (WGS) data...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 01a97ff1-49e5-59e4-b826-8d7b13c59d4a
DOI: 10.1101/2022.07.25.501144

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Extrachromosomal DNA in the cancerous transformation of Barrett’s esophagusDOI 10.1101/2022.07.25.501144Read

Evolution and progression of Barrett's oesophagus to oesophageal cancer.Semantic proximity Read

Somatic whole genome dynamics of precancer in Barrett’s EsophagusSemantic proximity Read

The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.Semantic proximity Read

Genomic copy number predicts oesophageal cancer years before transformationSemantic proximity Read

Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progressionSemantic proximity Read

Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” eraSemantic proximity Read

Complex structural rearrangements are present in high-grade dysplastic Barrett’s oesophagus samplesSemantic proximity Read

Integrated epidemiogical and genomic data yields insights into the relationship between precancer and cancer states of the oesophagusSemantic proximity Read

Disentangling oncogenic amplicons in esophageal adenocarcinomaSemantic proximity Read

Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal EvolutionSemantic proximity Read

Studying Cancer Evolution in Barrett's Esophagus and Esophageal Adenocarcinoma.Semantic proximity Read

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.Semantic proximity Read