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Article

Disentangling oncogenic amplicons in esophageal adenocarcinoma

14 May 2024

Abstract excerpt

Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly understood. Here, we use 710 esophageal adenocarcinoma cases with matched samples and patient-derived organoids to disentangle complex amplicons and their associated mechanisms....

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PMID: 38744814
DOI: 10.1038/s41467-024-47619-4

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