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Article

Evolution and progression of Barrett's oesophagus to oesophageal cancer.

Nature reviews. Cancer - 1 Nov 2021

Killcoyne Sarah, Fitzgerald Rebecca C

Abstract excerpt

Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection and population expansion. Early steps in this process are driven by a set of mutated driver genes and structural alterations to the genome through copy number gains or losses. Oesophageal adenocarcinoma (EAC) and the pre-invasive tissue, Barrett's oesophagus (BE), provide an ideal example in which to observe and study this...

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Identifiers

PMID: 34545238
DOI: 10.1038/s41568-021-00400-x

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