Article

Capturing differences in the regulation of LRRK2 dynamics and conformational states by small molecule kinase inhibitors

2022-10-25

Abstract excerpt

Mutations in the human leucine rich repeat protein kinase-2 (LRRK2) create risk factors for Parkinson’s Disease, and pathological functions of LRRK2 are often correlated with aberrant kinase activity. Past research has focused on developing selective LRRK2 kinase inhibitors. We showed previously that in addition to influencing intrinsic kinase activity, the global conformation of the LRRK2 protein plays a vital ro...

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Literature Corpus work: 83c232d9-f828-59e6-9b03-5c0b5bf06aaf
DOI: 10.1101/2022.10.24.513618

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