Article

Two helices control the dynamic crosstalk between the catalytic domains of LRRK2

2021-09-29

Abstract excerpt

The two major molecular switches in biology, kinases and GTPases, are both contained in the Parkinson’s Disease-related Leucine-rich repeat kinase 2 (LRRK2). Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and Molecular Dynamics (MD) simulations, we generated a comprehensive dynamic allosteric portrait of the C-terminal domains of LRRK2 (LRRK2 RCKW ). We identified two helices that shield the kinase...

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Literature Corpus work: 44fcc8da-d327-5cdd-b112-f25b37d56f38
DOI: 10.1101/2021.09.29.462278

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