Article
LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.
PLoS biology - 1 Feb 2022
Weng Jui-Hung, Aoto Phillip C, Lorenz Robin, Wu Jian, Schmidt Sven H, Manschwetus Jascha T, Kaila-Sharma Pallavi, Silletti Steve, Mathea Sebastian, Chatterjee Deep, Knapp Stefan, Herberg Friedrich W, Taylor Susan S
Abstract excerpt
The 2 major molecular switches in biology, kinases and GTPases, are both contained in the Parkinson disease-related leucine-rich repeat kinase 2 (LRRK2). Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and molecular dynamics (MD) simulations, we generated a comprehensive dynamic allosteric portrait of the C-terminal domains of LRRK2 (LRRK2RCKW). We identified 2 helices that shield the kinase domain...
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