Article

Proximity proteomics reveals a co-evolved LRRK2-regulatory network linked to centrosomes

2024-10-01

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) not only plays a vital role in familial forms of Parkinson’s disease (PD) but also represents a risk factor for idiopathic PD. Its multi-domain architecture enables fine-tuned regulation of its biological function by orchestrating intra- and intermolecular interactions. Here, we present BioID proximity proteomes of LRRK2 that reveal new interactors, which we further characteriz...

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Literature Corpus work: 921ed101-bb53-5d46-a5d9-649f670ffd37
DOI: 10.1101/2024.09.30.613622

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