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Article

Mutational fitness landscape of human influenza H3N2 neuraminidase.

Cell reports - 31 Jan 2023

Lei Ruipeng, Hernandez Garcia Andrea, Tan Timothy J C, Teo Qi Wen, Wang Yiquan, Zhang Xiwen, Luo Shitong, Nair Satish K, Peng Jian, Wu Nicholas C

Abstract excerpt

Influenza neuraminidase (NA) has received increasing attention as an effective vaccine target. However, its mutational tolerance is not well characterized. Here, the fitness effects of >6,000 mutations in human H3N2 NA are probed using deep mutational scanning. Our result shows that while its antigenic regions have high mutational tolerance, there are solvent-exposed regions with low mutational tolerance. We also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36640354
DOI: 10.1016/j.celrep.2022.111951
PMCID: PMC9931530

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