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Article

High-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolution.

Scientific reports - 13 May 2014

Wu Nicholas C, Young Arthur P, Al-Mawsawi Laith Q, Olson C Anders, Feng Jun, Qi Hangfei, Chen Shu-Hwa, Lu I-Hsuan, Lin Chung-Yen, Chin Robert G, Luan Harding H, Nguyen Nguyen, Nelson Stanley F, Li Xinmin, Wu Ting-Ting, Sun Ren

Abstract excerpt

Genetic research on influenza virus biology has been informed in large part by nucleotide variants present in seasonal or pandemic samples, or individual mutants generated in the laboratory, leaving a substantial part of the genome uncharacterized. Here, we have developed a single-nucleotide resolution genetic approach to interrogate the fitness effect of point mutations in 98% of the amino acid positions in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24820965
DOI: 10.1038/srep04942
PMCID: PMC4018626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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