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Article

The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin.

eLife - 8 Jul 2014

Thyagarajan Bargavi, Bloom Jesse D

Abstract excerpt

Influenza is notable for its evolutionary capacity to escape immunity targeting the viral hemagglutinin. We used deep mutational scanning to examine the extent to which a high inherent mutational tolerance contributes to this antigenic evolvability. We created mutant viruses that incorporate most of the ≈10(4) amino-acid mutations to hemagglutinin from A/WSN/1933 (H1N1) influenza. After passaging these viruses in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemagglutinin Glycoproteins, Influenza Virus

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Source

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Identifiers

PMID: 25006036
DOI: 10.7554/eLife.03300
PMCID: PMC4109307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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