Article
Emergence of Hemagglutinin Mutations During the Course of Influenza Infection.
Scientific reports - 5 Nov 2015
Cushing Anna, Kamali Amanda, Winters Mark, Hopmans Erik S, Bell John M, Grimes Susan M, Xia Li C, Zhang Nancy R, Moss Ronald B, Holodniy Mark, Ji Hanlee P
Abstract excerpt
Influenza remains a significant cause of disease mortality. The ongoing threat of influenza infection is partly attributable to the emergence of new mutations in the influenza genome. Among the influenza viral gene products, the hemagglutinin (HA) glycoprotein plays a critical role in influenza pathogenesis, is the target for vaccines and accumulates new mutations that may alter the efficacy of immunization. To...
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