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Article

Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants.

Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2018

Lee Juhye M, Huddleston John, Doud Michael B, Hooper Kathryn A, Wu Nicholas C, Bedford Trevor, Bloom Jesse D

Abstract excerpt

Human influenza virus rapidly accumulates mutations in its major surface protein hemagglutinin (HA). The evolutionary success of influenza virus lineages depends on how these mutations affect HA's functionality and antigenicity. Here we experimentally measure the effects on viral growth in cell culture of all single amino acid mutations to the HA from a recent human H3N2 influenza virus strain. We show that...

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Identifiers

PMID: 30104379
DOI: 10.1073/pnas.1806133115
PMCID: PMC6126756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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