Article

Single-cell analyses reveal a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer

2021-03-25

Abstract excerpt

<h4>ABSTRACT</h4> To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated 451,886 single-cell chromatin accessibility profiles and 208,557 single-cell transcriptomes from 48 polyps, 27 normal tissues, and 6 CRCs collected from patients with and without germline APC mutations. A large fraction of polyp...

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Literature Corpus work: 862bd58e-21dc-59cd-9a42-e68bb52da98d
DOI: 10.1101/2021.03.24.436532

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