Article

Temporal recording of mammalian development and precancer

2023-12-19

Abstract excerpt

Key to understanding many biological phenomena is knowing the temporal ordering of cellular events, which often require continuous direct observations [1, 2]. An alternative solution involves the utilization of irreversible genetic changes, such as naturally occurring mutations, to create indelible markers that enables retrospective temporal ordering [3-8]. Using NSC-seq, a newly designed and validated multi-purpo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a565422-bfaa-59b9-b9a9-c1d472a1a74c
DOI: 10.1101/2023.12.18.572260

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Temporal recording of mammalian development and precancerDOI 10.1101/2023.12.18.572260Read

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiationSemantic proximity Read

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiationSemantic proximity Read

Single-cell analyses reveal a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancerSemantic proximity Read

Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancerSemantic proximity Read

Lineage tracing of normal human development and childhood cancersSemantic proximity Read

Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damageSemantic proximity Read

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixtureSemantic proximity Read

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomicsSemantic proximity Read

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomicsSemantic proximity Read

High-depth Whole Genome Sequencing of Single Human Colon Crypts Uncovers New View on Crypt ClonalitySemantic proximity Read

High-confidence calling of normal epithelial cells allows identification of a novel stem-like cell state in the colorectal cancer microenvironment.Semantic proximity Read

Single Cell Integration Characterises Metaplasia in Inflammatory Intestinal DiseasesSemantic proximity Read