Article
Aging restricts colorectal tumor growth by epigenetically silencing developmental gene programs
2026-06-15
Abstract excerpt
The incidence of early-onset colorectal cancer (CRC) has risen sharply in recent decades1, yet the biological basis underlying the distinct behavior of tumors arising in young versus aged tissues remains poorly understood. Here we show that aging reprograms the epigenetic landscape of the colon, restricting colon tumor growth through stable silencing of developmental and fetal gene programs. We find that colon tum...
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Identifiers and source
- Literature Corpus work
- 53029bf1-9aa3-5733-9218-8ffb988e09ba
- DOI
- 10.64898/2026.06.12.731922