Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic signaling is coupled to colorectal cancer cell differentiation state.

The Journal of cell biology - 5 Jun 2023

Sell Thomas, Klotz Christian, Fischer Matthias M, Astaburuaga-García Rosario, Krug Susanne, Drost Jarno, Clevers Hans, Sers Christine, Morkel Markus, Blüthgen Nils

Abstract excerpt

Colorectal cancer progression is intrinsically linked to stepwise deregulation of the intestinal differentiation trajectory. In this process, sequential mutations of APC, KRAS, TP53, and SMAD4 enable oncogenic signaling and establish the hallmarks of cancer. Here, we use mass cytometry of isogenic human colon organoids and patient-derived cancer organoids to capture oncogenic signaling, cell phenotypes, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to Colorectal Neoplasms

Share to Intestines

Share to Mutation

Share to Oncogenes

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 37017636
DOI: 10.1083/jcb.202204001
PMCID: PMC10082329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic signaling is coupled to colorectal cancer cell differentiation state.PMID 37017636Read ↗

Oncogenic signalling is coupled to colorectal cancer cell differentiation stateSemantic proximity Read ↗

High-confidence calling of normal epithelial cells allows identification of a novel stem-like cell state in the colorectal cancer microenvironment.Semantic proximity Read ↗

High-confidence calling of normal epithelial cells allows identification of a novel stem-like cell state in the colorectal cancer microenvironmentSemantic proximity Read ↗

An oncogenic phenoscape of colonic stem cell polarizationSemantic proximity Read ↗

Perturbation-guided mapping of colorectal cancer cell states to causal mechanismsSemantic proximity Read ↗

Multi-omics, organoid-based modeling reveals an SRC/mTOR-dependent fetal-like stem cell trajectory in colorectal cancerSemantic proximity Read ↗

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancerSemantic proximity Read ↗

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epitheliumSemantic proximity Read ↗

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancerSemantic proximity Read ↗

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.Semantic proximity Read ↗

Integrated multi-omics analyses on patient-derived CRC organoids highlight altered molecular pathways in colorectal cancer progression involving PTENSemantic proximity Read ↗

Human colorectal pre-cancer atlas identifies distinct molecular programs underlying two major subclasses of pre-malignant tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.