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Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer

20 Jun 2022

Abstract excerpt

To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single-cell chromatin accessibility profiles and single-cell transcriptomes from 1,000 to 10,000 cells per sample for 48 polyps, 27 normal tissues and 6 CRCs collected from patients with or without germline APC mutations. A large fraction of polyp...

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PMID: 35726067
DOI: 10.1038/s41588-022-01088-x

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