Article

Epigenetic evolution of colorectal cancer and its microenvironment reveals new vulnerabilities

2026-08-11

Abstract excerpt

Epigenetics is central to tumorigenesis, but the co-evolution of the cancer epigenome and its microenvironment is severely understudied. Here, we measure chromatin accessibility and transcriptome, at single cell resolution, of a set of normal colon, primary colorectal cancers and metastases, and identify recurrent epigenetic alterations in tumour cells. We also found that the normal epithelium adjacent to the canc...

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Literature Corpus work: cae9add1-5e02-591a-a357-333d5aca8a2e
DOI: 10.64898/2026.08.10.743840

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