Article

Deletion of Setd7 protects against cardiac hypertrophy via inhibiting lipid oxidation

2024-07-30

Abstract excerpt

Setd7, a catalytic enzyme responsible for histone H3K4 methylation, is implicated in various cardiac diseases. However, the role of Setd7 in pathological cardiac hypertrophy remains unclear. In this study, we observed that Setd7 is significantly elevated in pathological hypertrophy stimuli cardiomyocytes and mouse failing hearts. Subsequently, we found that mice lacking Setd7 remarkably preserved cardiac function...

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Literature Corpus work: a1fdede1-d924-5482-8aae-2aa7ffe6aa02
DOI: 10.1101/2024.07.29.605718

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