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Article

Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction.

Circulation research - 14 Feb 2020

Hu Qingxun, Zhang Huiliang, Gutiérrez Cortés Nicolás, Wu Dan, Wang Pei, Zhang Jing, Mattison Julie A, Smith Eric, Bettcher Lisa F, Wang Mingyi, Lakatta Edward G, Sheu Shey-Shing, Wang Wang

Abstract excerpt

RATIONALE: Lipid overload-induced heart dysfunction is characterized by cardiomyocyte death, myocardial remodeling, and compromised contractility, but the impact of excessive lipid supply on cardiac function remains poorly understood. OBJECTIVE: To investigate the regulation and function of the mitochondrial fission protein Drp1 (dynamin-related protein 1) in lipid overload-induced cardiomyocyte death and heart...

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Identifiers

PMID: 31896304
DOI: 10.1161/CIRCRESAHA.119.315252
PMCID: PMC7035202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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