Article

ZDHHC14-Mediated Palmitoylation of TBK1 Promotes Pathological Cardiac Hypertrophy via Type I Interferon Signaling Activation

2026-07-26

Abstract excerpt

Pathological cardiac hypertrophy represents a common maladaptive response to cardiovascular stress and constitutes a major harbinger of heart failure. Although S-palmitoylation—a reversible post-translational modification—critically governs protein localization, trafficking, and stability, its involvement in cardiac hypertrophy remains poorly characterized. In this study, we aimed to explore the role and regulator...

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Literature Corpus work: c5a057c6-fb1a-5f11-9faa-607874e5442d
DOI: 10.64898/2026.07.24.740659

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ZDHHC14-Mediated Palmitoylation of TBK1 Promotes Pathological Cardiac Hypertrophy via Type I Interferon Signaling ActivationDOI 10.64898/2026.07.24.740659Read

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