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Article

Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction

21 Dec 2023

Abstract excerpt

BACKGROUND: Metabolic distress is often associated with heart failure with preserved ejection fraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced systemic inflammation links comorbidities with HFpEF. How metabolic changes affect myocardial inflammation in the context of HFpEF is not known. METHODS: cardiac cells to evaluate the involvement of inflammation in diastolic dysfunction. We...

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PMID: 38126199
DOI: 10.1161/circulationaha.122.062984

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