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The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis

2 Jan 2025

Abstract excerpt

Energy deprivation and metabolic rewiring of cardiomyocytes are widely recognized hallmarks of heart failure. Here, we report that HEY2 (a Hairy/Enhancer-of-split-related transcriptional repressor) is upregulated in hearts of patients with dilated cardiomyopathy. Induced Hey2 expression in zebrafish hearts or mammalian cardiomyocytes impairs mitochondrial respiration, accompanied by elevated ROS, resulting in...

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PMID: 39747914
DOI: 10.1038/s41467-024-55557-4

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