Article

Reactivation of Mthfd2 during heart failure drives cardiac remodeling

2025-12-17

Abstract excerpt

<title>Abstract</title> <p>Heart failure, particularly heart failure with preserved ejection fraction (HFpEF), is a prevalent clinical syndrome with limited therapeutic options, largely due to an incomplete understanding of its pathological mechanisms. Using systems genetics in the Hybrid Mouse Diversity Panel (HMDP), comprising about 100 inbred strains, we identified methylenetetrahydrofolate dehydrogenase 2 (Mt...

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Literature Corpus work: c1ca3ee1-3b99-5bf1-8ce3-9281a562833c
DOI: 10.21203/rs.3.rs-8325105/v1

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