Article
The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms.
Cell - 31 May 2018
Srinivasan Madhusudhan, Scheinost Johanna C, Petela Naomi J, Gligoris Thomas G, Wissler Maria, Ogushi Sugako, Collier James E, Voulgaris Menelaos, Kurze Alexander, Chan Kok-Lung, Hu Bin, Costanzo Vincenzo, Nasmyth Kim A
Abstract excerpt
As predicted by the notion that sister chromatid cohesion is mediated by entrapment of sister DNAs inside cohesin rings, there is perfect correlation between co-entrapment of circular minichromosomes and sister chromatid cohesion. In most cells where cohesin loads without conferring cohesion, it does so by entrapment of individual DNAs. However, cohesin with a hinge domain whose positively charged lumen is...
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