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Article

Cohesins: chromosomal proteins that prevent premature separation of sister chromatids.

Cell - 3 Oct 1997

Michaelis C, Ciosk R, Nasmyth K

Abstract excerpt

Cohesion between sister chromatids opposes the splitting force exerted by microtubules, and loss of this cohesion is responsible for the subsequent separation of sister chromatids during anaphase. We describe three chromosmal proteins that prevent premature separation of sister chromatids in yeast. Two, Smc1p and Smc3p, are members of the SMC family, which are putative ATPases with coiled-coil domains. A third...

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PMID: 9335333
DOI: 10.1016/s0092-8674(01)80007-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Cohesins: chromosomal proteins that prevent premature separation of sister chromatids.PMID 9335333Read ↗

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.Semantic proximity Read ↗

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.Semantic proximity Read ↗

SMC1B is present in mammalian somatic cells and interacts with mitotic cohesin proteins.Semantic proximity Read ↗

Structure and stability of cohesin's Smc1-kleisin interaction.Semantic proximity Read ↗

Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function.Semantic proximity Read ↗

Closing the cohesin ring: structure and function of its Smc3-kleisin interface.Semantic proximity Read ↗

Conserved disruptions in the predicted coiled-coil domains of eukaryotic SMC complexes: implications for structure and function.Semantic proximity Read ↗

Genetic evidence that the acetylation of the Smc3p subunit of cohesin modulates its ATP-bound state to promote cohesion establishment in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cornelia de Lange Syndrome mutations in SMC1A cause cohesion defects in yeast.Semantic proximity Read ↗

SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family.Semantic proximity Read ↗

Releasing Activity Disengages Cohesin's Smc3/Scc1 Interface in a Process Blocked by Acetylation.Semantic proximity Read ↗

Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cellsSemantic proximity Read ↗

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