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Article

Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation.

Current biology : CB - 6 Oct 2014

Ladurner Rene, Bhaskara Venugopal, Huis in 't Veld Pim J, Davidson Iain F, Kreidl Emanuel, Petzold Georg, Peters Jan-Michael

Abstract excerpt

BACKGROUND: Cohesin mediates sister chromatid cohesion by topologically entrapping sister DNA molecules inside its ring structure. Cohesin is loaded onto DNA by the Scc2/NIPBL-Scc4/MAU2-loading complex in a manner that depends on the adenosine triphosphatase (ATPase) activity of cohesin's Smc1 and Smc3 subunits. Subsequent cohesion establishment during DNA replication depends on Smc3 acetylation by Esco1 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomal Proteins, Non-Histone

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Source

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Identifiers

PMID: 25220052
DOI: 10.1016/j.cub.2014.08.011
PMCID: PMC4188815

Genes

MAU2
NIPBL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation.PMID 25220052Read ↗

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Closing the cohesin ring: structure and function of its Smc3-kleisin interface.Semantic proximity Read ↗

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Pds5 regulates sister chromatid cohesion by controlling cohesin ATPase activity through the Eco1-Smc3 acetylation pathway.Semantic proximity Read ↗

Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.Semantic proximity Read ↗

A molecular determinant for the establishment of sister chromatid cohesion.Semantic proximity Read ↗

Cohesin acetylation and ATPase activity control cohesion and loop architecture through distinct mechanisms.Semantic proximity Read ↗

The acetyltransferase Eco1 elicits cohesin dimerization during S phaseSemantic proximity Read ↗

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Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion.Semantic proximity Read ↗

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