Article

Efflux-linked Accelerated Evolution of Antibiotic Resistance at a Population Edge

2022-04-01

Abstract excerpt

<h4>SUMMARY</h4> Efflux is a common mechanism of resistance to antibiotics. We show that efflux itself promotes accumulation of antibiotic-resistance mutations (ARM). This phenomenon was initially discovered in a bacterial swarm where the linked phenotypes of high efflux and high mutation frequencies spatially segregated to the swarm edge, driven there by motility. We uncovered and validated a global regulatory n...

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Literature Corpus work: 00c2164d-085c-53ab-94a6-5b2dee36a0d8
DOI: 10.1101/2022.04.01.486762

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