Article

Efflux Pump Activation Confers Mupirocin Resistance and Enhances Rhizosphere Fitness in <i>Pseudomonas</i>

2026-01-05

Abstract excerpt

<h4>ABSTRACT</h4> Mupirocin (Mup) is a polyketide antibiotic for clinical MRSA treatment and agricultural biocontrol, acting by binding to IleRS to inhibit protein synthesis. Here, we demonstrate that Pseudomonas viciae 11K1 acquires resistance to mupirocin not through canonical mutations in ileS , the gene encoding the drug target, but via single nucleotide polymorphisms (SNPs) of EmhR, a transcriptional repre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6244dc53-43ce-5f03-828e-81c9bfc66f4a
DOI: 10.64898/2026.01.05.697689

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Efflux Pump Activation Confers Mupirocin Resistance and Enhances Rhizosphere Fitness in <i>Pseudomonas</i>DOI 10.64898/2026.01.05.697689Read

Efflux pump activation confers mupirocin resistance and enhances rhizosphere fitness in Pseudomonas.Semantic proximity Read

Keeping up with the pathogens: Improved antimicrobial resistance detection and prediction from<i>Pseudomonas</i>aeruginosa genomesSemantic proximity Read

Allele-Specific Effects of Mutations in the Rifampin Resistance-Determining Region (RRDR) of RpoB on Physiology and Antibiotic Resistance in <i>Enterococcus faecium</i>Semantic proximity Read

Strain-resolved CRISPRi-Seq reveals conserved antibiotic vulnerabilities in <i>Staphylococcus aureus</i>Semantic proximity Read

Novel regulatory logic in the antibiotic resistance response of <i>Enterococcus faecalis</i> against cell envelope targeting antibioticsSemantic proximity Read

Genetic determinants of virulence and extensive drug resistance in <i>Pseudomonas aeruginosa</i> PPA14 isolated from eggplant rhizosphereSemantic proximity Read

Antibiotic-adjuvants abolish resistance conferred by the <i>Staphylococcus aureus</i> erythromycin resistance methyltransferase in an <i>Escherichia coli</i> modelSemantic proximity Read

Exploring mechanisms of mupirocin resistance and hyper-resistanceSemantic proximity Read

The fitness landscape of the mobilized colistin resistance gene <i>mcr-1</i>Semantic proximity Read

Heteroresistance in <i>Enterococcus faecalis</i> is prevalent for key antibiotics and mainly caused by mutationsSemantic proximity Read

Genome-wide analyses reveal antibiotic resistance genes and mechanisms in pathogenic Pseudomonas bacteriaSemantic proximity Read

A preclinical resistance framework discovers the virulence risks of antibiotics in developmentSemantic proximity Read