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Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivo

2024-11-12

Abstract excerpt

<title>Abstract</title> <p>Antibiotic resistance is one of the most pressing threats to human health, yet recent work highlights how loss of resistance may also drive pathogenesis in some bacteria. In two recent studies, we found that β-lactam antibiotic and nutrient stresses faced during infection selected for the genetic inactivation of the Pseudomonas aeruginosa (Pa) antibiotic efflux pump mexEFoprN. Unexpecte...

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Literature Corpus work
37d53a0b-66dc-5cdc-8371-b27d0d3cc657
DOI
10.21203/rs.3.rs-5391023/v1
Open publication

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Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivoDOI 10.21203/rs.3.rs-5391023/v1
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